CoQ10

Overview

CoQ10 is a lipid-soluble antioxidant found in every cell in the body. CoQ10 is abundant in the mitochondrial membrane and plays an important role in the synthesis of adenosine triphosphate (ATP), a molecule of chemical energy upon which all cellular functions depend. The synthesis of ATP within the mitochondria is a multi-step series of biochemical reactions called the electron transport chain. As a coenzyme, CoQ10 is required for several enzymatic reactions required to produce cellular energy and to protect the body against free radicals produced during this process. To maintain energy production, mitochondrial CoQ10 is continuously recycled from ubiquinone, its ATP production state, to ubiquinol, its antioxidant state. After the age of 35 to 40 years, endogenous synthesis of CoQ10 begins to decline.1 CoQ10, an essential component of cellular energy production, has been shown to extend cell life and benefit high-energy systems, namely the cardiovascular, neurological and immune systems.

CoQ10 Depletion†

The body’s ability to produce and metabolize CoQ10 has been reported to decrease with age. CoQ10 deficiency may be caused by insufficient dietary intake of CoQ10, impairment in CoQ10 production, drug-induced CoQ10 depletion, gene mutations and oxidative stress. HMG-CoA reductase is an enzyme required for the synthesis of cholesterol and CoQ10. Cholesterol lowering medications inhibit this enzyme in order to reduce cholesterol synthesis, but may also simultaneously deplete CoQ10 status. Thirteen controlled studies conducted between 1990-2004 demonstrated significant CoQ10 depletion, secondary to use of statin medications used to lower cholesterol levels.2 These studies demonstrated a range of 19- 54% decrease in CoQ10 levels in patients on statin therapy. In the event of CoQ10 depletion, supplementation can improve CoQ10 status and help maintain optimal levels in the body.

Cardiovascular Health†

CoQ10 is important for all energy-dependent processes, and is especially helpful in strengthening contraction of the heart muscle. CoQ10 is also important for protection against free radical damage to the arterial vessels. In a double-blind, crossover trial 19 patients received 100 mg CoQ10/day or placebo for 12 weeks. Compared with placebo, patients receiving CoQ10 demonstrated significant support of cardiac function and increased tolerance for physical activity.3 In another study, 109 patients received an average dose of 225 mg of CoQ10 per day. After a mean treatment period of 4.4 months, CoQ10 helped in maintaining healthy blood pressure levels in more than half of the patients.4 CoQ10 has been shown to be a preventive factor in reducing low-density lipoprotein (LDL) oxidation- a major factor for supporting healthy cholesterol levels.5

Blood Sugar Balance†

The electron transport chain, a biochemical pathway in which CoQ10 plays a major role, significantly impacts carbohydrate metabolism. CoQ10 has been shown to support blood sugar balance already within normal levels.7 In one study, 39 subjects received 120mg of a CoQ10 analog for 2-18 weeks. Fasting blood sugar levels were maintained in the normal range, along with a 30% decrease of ketone bodies in 59% of patients- an indicator of healthy blood sugar metabolism.8

Neurological Health†

Neurons are characterized by high rates of metabolic activity and the need to respond quickly to energy demanding fluctuations in the brain. Mitochondrial alterations, leading to reduced ATP production, can promote neuronal dysfunction and degeneration via increased production of reactive oxygen species in the central nervous system. As an effective carrier with strong antioxidant properties, CoQ10 has been shown to promote neurological health.9 Directions 1 or more soft gel capsules per day or as recommended by your health care professional. Does Not Contain Gluten, corn, artificial colors or flavors.Cautions If you are pregnant or nursing, consult your health care professional before taking this product.

References

1.Hargreaves IP, Duncan AJ, Heales SJ, Land JM. The effect of HMG-CoA reductase inhibitors on coenzyme Q10: possible biochemical/clinical implications. Drug Saf 2005;28:659-676. 3. Langsjoen PH, Vadhanavikit S, Folkers K. Effective treatment with coenzyme Q10 of patients with chronic myocardial disease. Drugs Explt Clin Res 1985;11:577-579. 2. Langsjoen P, Langsjoen P, Willis R, Folkers K. Treatment of essential hypertension with Coenzyme Q10. Molec Aspects Med 1994;15(Suppl):S265-S272. 5. Stocker R, Bowry VW, Frei B. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proc Natl Acad Sci 1991; 88(5):1646-50. 3. Gaby AR. The role of coenzyme q10 in clinical medicine: Part II. Cardiovascular disease, hypertension, diabetes mellitus and infertility. Altern Med Review 1996; 1(3):168- 175. 4 Shigeta Y, Izumi K. Abe H. Effect of coenzyme Q7 treatment on blood sugar and ketone bodies of diabetics. J Vitaminol 1966;12:293-298. 5. Mancuso M, Orsucci D, Calsolaro V, Choub A, Siciliano G. Coenzyme Q10 and Neurological Diseases. Pharmaceuticals 2009; 2:134-149. ID# 120030 30 Soft Gel Capsules ID# 120060 60 Soft Gel Capsules ID# 120120 120 Soft Gel Capsules LT-PDN-186-A DATE 10-24-1