Sleep Max | Sleep Supplements
$36.70 – $176.16 — or from $29.36 – $140.93 / month
SUPPORTS RESTORATIVE SLEEP Increases natural melatonin production and promotes healthy sleep cycles to give you the restful sleep and relaxation your body needs.
HELPS REDUCE elevated levels of the stress hormone cortisol
SUPPORTS RESTFUL night’s sleep by increasing levels of calming brain chemicals through the use of taurine
Science & Clinically
EXPERTLY DESIGNED FORMULAS BECAUSE EFFICACY MATTERS
Sleep Max is one of the most comprehensive sleep formulas available on the market today
How does it work?
Sleep Max is a unique science-based formulation designed to help you overcome occasional sleep disturbances. Our comprehensive blend of natural ingredients provides amino acids and bioactive nutrients to boost your body’s sleep-regulating neurotransmitters. You’ll enjoy more relaxation while optimizing sleep cycle regulation, allowing you to wake up feeling rested and rejuvenated, and ready to take on each new day.
Not many things are worse than tossing and turning all night long. If you’re suffering from sleep disorders, you’re far from alone. In today’s stressful world, the Centers for Disease Control and Prevention says insomnia is so common it has reached epidemic levels. Sleep is so important because it’s your body’s way of metabolically and psychologically resetting itself.
Without adequate sleep, you may experience decreased immune function, memory problems, lower productivity, reduced alertness, poor judgement, shorter attention spans, difficulty concentrating and more accident prone.
Dr. Nandi’s Sleep Max is your safe and effective solution to get the restorative sleep you need every night.
Sleep Max is a comprehensive formulation created for patients experiencing occasional sleeplessness. Sleep Max promotes a healthy sleep cycle by naturally boosting levels of serotonin, GABA and melatonin using bioactive cofactors and amino acids. Phosphatidylserine is also included as a vital ingredient for those with elevated evening cortisol levels that may be contributing to frequent waking.
Sleep is the body’s way of metabolically and psychologically resetting itself. The body’s circadian rhythm is regulated by an internal biological clock with an approximate 24-hour cycle. In order to maintain restorative sleep, it is crucial that the brain has optimal levels of serotonin and gamma-aminobutyric acid (GABA), the relaxing and sleep-regulating neurotransmitters, as well as the sleep-regulating hormone melatonin. The synergistic ingredients in Sleep Max boost levels of the neurotransmitters and hormones that promote relaxation prior to bedtime and increase the deep, restorative stages of sleep.
The sleep-regulating hormone melatonin requires the essential amino acid L-tryptophan for conversion. A deficiency of L-tryptophan in the diet can lead to low serotonin and melatonin levels, which can contribute to sleep challenges. L-tryptophan is converted into the amino acid intermediate 5-hydroxytryptophan (5-HTP), which is then converted directly into serotonin, followed by melatonin conversion. While L-tryptophan is the starting block for serotonin and melatonin production, one of the key advantages of 5-HTP is its ability to easily cross the blood brain barrier. This allows for enhanced serotonin and melatonin synthesis. Clinical studies have demonstrated the ability of 5-HTP to promote and enhance sleep. 5-HTP increases REM sleep by about 25%, while increasing deep sleep stages 3 and 4, without lengthening total sleep time.1,2 Non-REM stages 1 and 2, the least important stages, are reduced to compensate for this increase, resulting in an increase in sleep efficiency.1,2 5-HTP has also been shown to be far more effective in promoting sleep when compared to L-tryptophan.3,4
Gamma-aminobutyric acid (GABA) is one of the major inhibitory neurotransmitters in the brain. GABA provides a calming effect and plays a direct role in activating the sleep cycle in the evening. Sleep Max includes a patented, naturally sourced, non-synthetic form of GABA called PharmaGABA®. In a study utilizing 100 mg of PharmaGABA®, supplemented before bedtime, PharmaGABA® was shown to reduce sleep latency by 20%, while increasing time spent in a deep sleep by 20%.5 PharmaGABA® has also been shown by electroencephalogram (EEG) readings to increase the ratio of alpha to beta waves in the brain, resulting in a calm and effortless state of relaxation.6]
Phosphatidylserine (PS) is a phospholipid found in high concentrations in the brain. Phosphatidylserine has been shown to play a role in regulating cortisol excretion. Elevated levels of cortisol throughout the night can contribute to frequent waking. In studies administering PS (50-800mg) to subjects under high levels of stress (physical and mental), PS was shown to reduce stress-induced secretion of cortisol.7,8 When taken in the evening, PS can help reduce cortisol excretion from the body’s stress response system, the hypothalamic-pituitaryadrenal (HPA) axis, in order to promote a healthy sleep cycle.
ENDOCRINE HEALTH †
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Taurine is an amino acid that is found abundantly in the brain and has neuroprotective properties.9 Taurine promotes inhibitory neurotransmission by activating GABA receptors.9. Taurine also supports inhibitory neurotransmission by activating glycine receptors in the brain.10
Calcium and magnesium are two minerals that play a major role in supporting a healthy sleep cycle. Magnesium calms the nervous system and has been shown to play a role in the regulation of the HPA axis. Magnesium promotes relaxation by decreasing the activity of glutamate, the primary excitatory (stimulating) neurotransmitter in the brain. Magnesium blocks glutamate from binding to its receptor, allowing for an increase in GABA activity, which activates the sleep cycle. Within the HPA axis, the body’s stress response system, magnesium has also been shown to decrease the release of the stress hormone cortisol, following oral magnesium administration.11Serotonin concentrations in the brain decrease by more than 80% after the onset of darkness. This is when serotonin is converted into melatonin in the pineal gland. Calcium ions are a critical requirement in the synthesis of melatonin.12 The combination of 5-HTP and calcium in Sleep Max provides a significant and natural boost to melatonin levels, aiding in the conversion and activation of this crucial sleep hormone.
Sleep Max includes essential nutrients that are required cofactors for the synthesis of serotonin and GABA. This includes 5-methyltetrahydrofolate (5-MTHF), vitamin B6 (P-5-P), vitamin C, zinc and magnesium to enhance neurotransmitter synthesis.
Directions – 4 capsules taken 1-2 hours before bedtime or as recommended by your health care professional.
Does Not Contain Gluten, artificial colors or flavors.
Do not consume this product if you are pregnant or nursing. Consult with your health care professional for further information.
1. Zarcone Jr VP, Hoodes E. Effects of 5-hydroxytryptophan on fragmentation of REM sleep in alcoholics. Am J Pchychiarty 1975;132:74-76. 2. Soulairac A, Lambinet H. Effect of 5-hydroxytryptophan, a serotonin precursor, on sleep disorders. Ann Med Psychol 1977;1:792-798. 3. Wyatt RJ, Zarcone V, Engelman K. Effects of 5-hydroxytryptophan on the sleep of normal human subjects. Electronecephalogr Clin Neurophysiol 1972;30:505-509. 4. Wyatt RJ. The serotonin-catecholamine-dream bicycle: a clinical study. Biol Psychiatry 1972:5:33-64. 5. Unpublished data provided by Pharma Foods International LTD., Kyoto, Japan. 6. Abdou AL, et al. Relaxation and immunity enhancement effects of γ-aminobutyric acid (GABA) administration in humans. Biofactors 2006;26:201-208. 7. Monteleone P, Maj M, et al. Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men. Eur J Clin Pharmacol 1992; 42(4):385-388. 8. Monteleone P, Beinat L, et al. Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans. Neuroendocrinology 1990; 52(3):243-248. 9. Albrecht J, Zielinska M. The role of inhibitory amino acidergic neurotransmission in hepatic encephalopathy: a critical overview. Metab Brain Dis; 2002 Dec; 17(4): 283:294. 10. Jia F, Yue M, Chandra S, Keramidas A, Goldstein PA, Homanics GE, Harrison NL. Taurine is a potent activator of extrasynaptic GABA(A) receptors in the thalamus. J Neurosci; 2008 28(1):106115. 11. Held K, Antonijevic IA, Kunzel H. Oral Mg2+ supplementation reverses age-related neuroendocrine and sleep EEG changes in humans. Pharmacopsych 2002;35:135-143. 12. Jolanta B. Zawilska. The role of calcium in the regulation of melatonin biosynthesis in the retina. Act Neurbiol Exp 1992;52:265274. 13. Kaplan, Bonnie J, Crawford, et al. Vitamin, minerals, and mood. Psychological Bulletin 2007; Vol 133(5):747-760.
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