Autoimmune disease is the scourge of the modern era. When your body goes haywire and begins attacking itself, it has many uncomfortable symptoms and health problems. There are over 80 types of autoimmune diseases that affect millions worldwide.

In this article, you will learn what autoimmune diseases are, what causes them, their symptoms and standard types, how to diagnose them, and how to treat them.

What Is an Autoimmune Disease?

Your immune system can tell the difference between cells and foreign cells in a healthy body. It protects its healthy cells from invaders, like bacteria and viruses. If you have an autoimmune disease, your body can’t differentiate between cells and invaders. When your immune system mistakenly attacks your body and causes health problems, it is called an autoimmune disease. Some autoimmune conditions, such as type 1 diabetes, target one organ only; others, such as lupus, affect the entire body. (1)

What Causes Autoimmune Disease?

The exact cause of autoimmune diseases is not fully clear yet. The investigation is ongoing to understand it fully.

Autoimmune conditions affect twice as many women as men and often start during the childbearing years between 14 and 44. Some autoimmune diseases are more prevalent among certain ethnicities. For example, lupus is more common among Black and Hispanic individuals. Certain autoimmune conditions, such as lupus and multiple sclerosis (MS), may also run in families.

It seems that diet, lifestyle, and environmental factors likely play a role in the rise of autoimmune diseases.

The Western diet, high in refined sugar, processed foods, and unhealthy fats, can lead to inflammation in the body and trigger autoimmune diseases.

Environmental factors, such as infections and exposure to certain chemicals, can also.

Fear of germs, too much attention to hygiene, and a lot of antiseptic use can make kids weaker, in the long run, say some people. They think this can make them more sensitive to harmless things later in life. (2, 3, 4, 5)

Common Autoimmune Diseases

There are over 80 different autoimmune diseases identified so far. There may be more that are unknown. Here are the 14 most common autoimmune diseases (6, 7, 8, 9, 10, 11, 12, 13):

  • Type 1 diabetes: In type 1 diabetes, the immune system attacks and kills insulin-producing cells in the pancreas. Insulin plays a vital role in regulating blood sugar. Blood sugar issues can lead to weight, heart, kidney, and nerve issues.
  • Rheumatoid arthritis (RA): Osteoarthritis tends to affect the older generation. However, RA can start at a young age, even in your 30s. As the immune system attacks the joints, RA leads to stiffness, pain, soreness, warmth, and redness.
  • Psoriasis/psoriatic arthritis: Psoriasis is an autoimmune condition that affects the growth of skin cells, speeding it up, leading to red, scaly patches and skin plaque. In 30 percent of people, it can also lead to psoriatic arthritis, which causes pain, stiffness, and swelling in the joints.
  • Multiple sclerosis (MS): MS damages the protective coating around nerve cells, called the myelin sheath, that interrupts the messages between the brain and the body. This disease leads to numbness, weakness, balance problems, and trouble walking.
  • Lupus: Lupus affects the entire body, including the joints, kidneys, heart, and brain. It can lead to pain, rashes, and fatigue.
  • Inflammatory bowel disease (IBD): IBD is the intestinal lining inflammation. Two common types of IBD are Crohn’s disease. They cause inflammation at any part of the GI tract and ulcerative colitis, affecting the large intestine and rectum.
  • Addison’s diseases: Addison’s disease affects the adrenal glands, leading to hormonal problems, low blood sugar, fatigue, weight loss, and weakness.
  • Graves’ disease: Graves’ disease is an autoimmune condition that affects the thyroid gland. The thyroid produces too many hormones, so weight loss, rapid heartbeat, nervousness, and heat intolerance arise.
  • Hashimoto’s thyroiditis: Hashimoto’s also affects the thyroid gland but leads to slow hormone production, weight gain, sensitivity to cold, fatigue, hair loss, and goiter.
  • Sjögren’s syndrome: Sjögren’s syndrome affects the joints and the lubrication of the mouth and eyes.
  • Myasthenia gravis: Myasthenia gravis affects the nerves in the brain that control your muscles, leading to muscle weakness, fatigue, swallowing problems, and issues with facial movement.
  • Vasculitis: Vasculitis affects the blood vessels, allowing less blood flow.
  • Pernicious anemia: Pernicious anemia affects the intrinsic factor, a protein that helps B12 absorption, leading to low red blood cell count. It is more common among older people.
  • Celiac disease: When people with celiac disease eat gluten, their immune system attacks their intestines, causing inflammation. People with celiac must avoid gluten altogether. It is not to be confused with gluten allergy or sensitivity.

Symptoms of Autoimmune Diseases

While symptoms vary from condition to condition, some symptoms can be very similar, especially early signs. They may include:

  • Fatigue
  • Achy muscles
  • Swelling and redness
  • Hair loss
  • Tingling and numbness in feet and hands
  • Trouble concentrating
  • Low-grade fever
  • Skin Rashes

Some autoimmune diseases show up with specific symptoms. Type 1 diabetics may be very thirsty and lose a lot of weight. IBD is caused by bloating, abdominal pain, and diarrhea, and these things happen when you have IBD. Psoriasis has certain rashes.

Some autoimmune diseases, such as RA and psoriasis, can go into remission. Symptoms may disappear for months or years, then suddenly flare up and come back for days, months, or years. Other autoimmune diseases don’t come and go. Celiac disease must be dealt with all the time. Gluten must always be avoided, no matter what the symptoms are.

When to See a Doctor

If you experience any of these conditions, you need to visit a doctor. You will likely need a specialist. Gastroenterologists treat celiac and IBD. Endocrinologists work with patients with Graves’ disease, Hashimoto’s, and Addison’s disease. Dermatologists can address psoriasis—rheumatologists help patients with RA. Your general practitioner can direct you to the best specialist to diagnose and treat your specific condition. (14, 17, 18)

Diagnosis of Autoimmune Diseases

Diagnosis and testing depending on the autoimmune condition. There is no single test for most conditions but an assessment of symptoms and some other testing that can help lead to a diagnosis. An antinuclear antibody test (ANA) can help identify the likelihood of an autoimmune condition. Your doctor may check for inflammation markers. With IBD, you may need a colonoscopy, and celiac requires a specific blood test. (14, 15, 16, 17, 18)

Treatment of Autoimmune Diseases

There is no cure for autoimmune diseases. Treatment can control the overactive immune response, lower inflammation, reduce symptoms, and in some cases, lead to remission.

Treatment depends on the type of autoimmune condition itself. Nonsteroidal anti-inflammatory drugs (NSAIDs) and immuno-suppressing drugs are often used. Type 1 diabetics need insulin. The treatment of psoriasis may involve using topical treatments.

In celiac disease, avoiding gluten at all costs, including cross-contamination, is essential.

Dietary and lifestyle changes can make an enormous difference in the outcome of most autoimmune conditions. They remove refined sugar, processed foods, artificial ingredients, and inflammatory foods. Eating an anti-inflammatory, fiber-rich, and nutrient-dense whole foods diet rich in greens, vegetables, and fruits. Getting regular exercise can also help you feel better. Identifying and avoiding dietary, environmental, and lifestyle triggers can make a huge difference. (17, 19)

If you suspect an autoimmune condition, visit your doctor for a proper diagnosis and find the right treatment. Dietary and lifestyle changes, avoiding triggers, lowering inflammation, and in some cases, using the appropriate medication lower your symptoms and even help you experience remission.


  1. https://www.ncbi.nlm.nih.gov/pubmed/22387972
  2. http://pubs.sciepub.com/ijcd/3/4/8/
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034518/
  4. https://link.springer.com/article/10.1007%2Fs12016-011-8285-8
  5. https://www.hopkinsmedicine.org/health/healthy-woman/conditions/what-are-common-symptoms-of-autoimmune-disease
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036413/
  7. https://academic.oup.com/rheumatology/article/53/4/671/1842242
  8. https://www.nejm.org/doi/full/10.1056/NEJMra1505557
  9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351877/
  10. https://www.nejm.org/doi/full/10.1056/NEJMra1100359
  11. https://www.nejm.org/doi/full/10.1056/NEJMra1510030
  12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596973/
  13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441227/
  14. https://www.womenshealth.gov/a-z-topics/autoimmune-diseases
  15. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832720/
  16. https://blog.uvahealth.com/2014/10/31/detective-work-autoimmune-disease/
  17. https://medlineplus.gov/autoimmunediseases.html
  18. https://www.med.unc.edu/medicine/news/chairs-corner/podcast/autoimmune-unclear-diagnosis
  19. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061980/

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